Metabolic & Obesity Research//Research Reference

Tirzepatide

Synthetic acylated peptide and dual GIP/GLP-1 receptor co-agonist; FDA-approved (Mounjaro, Zepbound) for type 2 diabetes and chronic weight management - this entry is a research-reference summary, not an approved drug product.

Technical Dossier

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Test Date

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Classification

Synthetic acylated 39-amino-acid peptide; dual GIP/GLP-1 receptor co-agonist

Mechanism / Biological Target

Activates both the GIP and GLP-1 receptors, increasing glucose-dependent insulin secretion, suppressing glucagon, slowing gastric emptying, and reducing appetite.

Research Areas

MetabolismObesityType 2 Diabetes

Research Overview

Tirzepatide is a synthetic 39-amino-acid acylated peptide and the first dual GIP and GLP-1 receptor co-agonist. The FDA approved tirzepatide (Mounjaro) in May 2022 for type 2 diabetes and (Zepbound) in November 2023 for chronic weight management, based on the SURPASS and SURMOUNT trials. This catalog entry is a research-reference summary only and does not represent or offer an approved pharmaceutical product. Approved products are distinct from research-grade material. Known risks include gastrointestinal adverse effects and, per labeling, concerns in specific populations; use requires medical supervision.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes
Heerspink HJW, et al. (review), 2022.
Tirzepatide (StatPearls)
NCBI Bookshelf / StatPearls, 2024.
FDA Approves New Medication for Chronic Weight Management (Zepbound/tirzepatide)
FDA press announcement, November 2023.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.