Endocrine Research//Research Reference

Tesamorelin + Ipamorelin

Peptide-blend reference of tesamorelin (an FDA-approved GHRH analog, Egrifta) and ipamorelin (a GHRP/ghrelin-receptor agonist); evidence exists for the components separately, not for the combination.

Composition

Composition pending verification

Technical Dossier

Batch / Lot Number

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Testing Status

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Testing Laboratory

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Test Date

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Classification

Peptide blend: tesamorelin (GHRF/GHRH analog) + ipamorelin (GHRP / ghrelin-receptor agonist)

Mechanism / Biological Target

Tesamorelin acts at the pituitary GHRH receptor to stimulate endogenous GH release; ipamorelin acts via the ghrelin/GHS receptor. Combined GHRH + GHRP stimulation is synergistic in experimental models.

Research Areas

EndocrinologyGrowth Hormone Axis

Research Overview

This entry is a combination/blend reference describing two compounds: tesamorelin (a synthetic GHRH/GRF analog - FDA-approved as Egrifta for HIV-associated lipodystrophy) and ipamorelin (a synthetic pentapeptide GHRP/ghrelin-receptor agonist). GHRH and GHRP pathways act synergistically to stimulate GH release in experimental studies, but robust clinical evidence specifically for this fixed combination is lacking; most data concern the individual components. The approved tesamorelin product is distinct from research-grade material. No combination efficacy is claimed. Not an approved combination drug.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy
McCullagh R, Waaijers S. (review), 2011.
Tesamorelin: a growth hormone-releasing factor analogue (FDA approval 2010)
Annals of Pharmacotherapy, 2012.
Ipamorelin, the first selective growth hormone secretagogue
Raun K, et al. European Journal of Endocrinology, 1998.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.