Endocrine Research//Research Reference
Tesamorelin
Synthetic GHRH analog; an FDA-approved drug (Egrifta) for HIV-associated lipodystrophy, distinct from research-grade material.
Technical Dossier
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Testing Status
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Testing Laboratory
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Test Date
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Classification
Growth hormone-releasing hormone (GHRH) analog
Mechanism / Biological Target
An analog of GHRH that stimulates pituitary release of endogenous growth hormone, secondarily increasing IGF-1, with a net effect of reducing visceral adipose tissue in the approved HIV-associated lipodystrophy indication.
Research Areas
EndocrinologyHIV-Associated LipodystrophyBody Composition
Research Overview
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). The FDA approved tesamorelin (Egrifta) in November 2010 as the first treatment indicated to reduce excess visceral abdominal fat in adults with HIV-associated lipodystrophy, based on phase 3 trials showing reductions in visceral adipose tissue. This entry describes the compound as a research-reference topic only. The approved pharmaceutical product (Egrifta / Egrifta WR) is distinct from any research-grade material and is not represented or offered by this catalog entry.
Laboratory Storage & Handling
For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.
References
- Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy
Drugs (review), 2011.
- Growth hormone and tesamorelin in the management of HIV-associated lipodystrophy
Bedimo R, et al. 2011.
- FDA Approves Tesamorelin for HIV Lipodystrophy
Medscape Medical News (FDA approval notice), November 12, 2010.
Related Research
Available Documentation
- Certificate of AnalysisPending / Not yet available
For Research Use Only
Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.