Tissue Repair & Regeneration Research//Research Reference

TB-500

Synthetic peptide designation related to thymosin beta-4, studied in preclinical tissue-repair models.

Technical Dossier

Batch / Lot Number

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Testing Status

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Testing Laboratory

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Test Date

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Classification

Commercial peptide designation related to thymosin beta-4

Mechanism / Biological Target

Thymosin beta-4 is an actin-sequestering peptide that influences actin polymerization dynamics, cell migration, angiogenesis, and anti-apoptotic signaling. Whether commercial TB-500 products reproduce these activities has not been established in controlled human trials.

Research Areas

Tissue RepairWound HealingMusculoskeletal Regeneration

Research Overview

TB-500 is a commercially used designation for synthetic peptide products marketed as related to thymosin beta-4 (TB4), a naturally occurring 43-amino-acid peptide. TB4 has been studied for roles in angiogenesis, cell migration, and wound healing, largely in animal and in vitro models. Clinical evidence specifically for TB-500 is limited, and the term is used variably across commercial, regulatory, and research contexts. TB-500 is not an approved drug.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

Thymosin beta4 accelerates wound healing
Malinda KM, et al. Journal of Investigative Dermatology, 1999.
Progress on the Function and Application of Thymosin beta-4
Xing Y, Ye Y, Zuo H, Li Y. Frontiers in Endocrinology, 2021.
Thymosin Beta-4 and TB-500 in Tissue Healing, Regeneration, and Musculoskeletal Repair: A Scoping Review
Applied Sciences (scoping review), 2024.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.