Endocrine Research//Research Reference

Sermorelin

Synthetic GHRH(1-29) analog (growth hormone-releasing hormone fragment); historically FDA-approved as Geref, now without a currently marketed FDA-approved product.

Technical Dossier

Batch / Lot Number

—

Testing Status

—

Testing Laboratory

—

Test Date

—

Classification

Synthetic GHRH(1-29) analog (growth hormone-releasing hormone fragment)

Mechanism / Biological Target

Binds and activates the pituitary GHRH receptor (Gs/cAMP), stimulating endogenous pulsatile GH release; short half-life (~8 minutes) relative to longer-acting GHRH analogs.

Research Areas

EndocrinologyGrowth Hormone Axis

Research Overview

Sermorelin is a synthetic 29-amino-acid analog of human growth hormone-releasing hormone (GHRH 1-29) that stimulates pituitary GH release. It was FDA-approved in the 1990s as Geref for diagnosis and treatment of pediatric growth hormone deficiency; the NDA was withdrawn in 2009 for commercial (not safety/effectiveness) reasons per a 2013 FDA Federal Register notice, and no FDA-approved sermorelin product is currently marketed in the US. It has been studied in aging/GH-insufficiency contexts. This entry is a research-reference summary and does not represent a currently marketed approved product.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency
Prakash A, Goa KL. BioDrugs (review), 1999.
Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?
Walker RF. Clinical Interventions in Aging, 2006.
Determination That GEREF (Sermorelin Acetate) Injection Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness
FDA, Federal Register, 2013.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.