Metabolic & Mitochondrial Research//Research Reference
MOTS-c
Mitochondrial-derived 16-amino-acid peptide investigated in metabolic and exercise physiology research.
Technical Dossier
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Classification
Mitochondrial-derived 16-amino-acid peptide
Mechanism / Biological Target
Acts through the folate-AICAR-AMPK pathway to influence glucose metabolism and mitochondrial homeostasis. Exercise increases endogenous MOTS-c levels in human skeletal muscle and circulation in reported studies.
Research Areas
MetabolismInsulin SensitivityExercise PhysiologyAging
Research Overview
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded by a short open reading frame in mitochondrial DNA. Studies in mice and limited human exercise studies suggest roles in insulin sensitivity, glucose metabolism, and exercise adaptation via AMPK signaling. MOTS-c is an investigational research peptide with no approved therapeutic use.
Laboratory Storage & Handling
For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.
References
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, et al. Cell Metabolism, 2015.
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC, et al. Nature Communications, 2021.
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation (review)
Review, 2023.
Related Research
Available Documentation
- Certificate of AnalysisPending / Not yet available
For Research Use Only
Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.