Immunology & Antimicrobial Research//Research Reference

LL-37

Human cathelicidin antimicrobial peptide (hCAP-18 C-terminal fragment LL-37); studied for antimicrobial and immunomodulatory activity.

Technical Dossier

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Testing Status

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Testing Laboratory

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Test Date

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Classification

Human cathelicidin antimicrobial peptide (hCAP-18 C-terminal fragment, LL-37)

Mechanism / Biological Target

Disrupts microbial membranes via cationic amphipathic interaction and modulates host immunity (chemotaxis, cytokine regulation, immune-cell activation) through receptors such as FPR2/FPRL1.

Research Areas

Antimicrobial DefenseImmunomodulationAnti-Biofilm

Research Overview

LL-37 is the C-terminal 37-amino-acid active fragment of human cathelicidin (hCAP-18) and a key human cationic host-defense peptide. It exhibits direct antimicrobial activity against bacteria and fungi and broad immunomodulatory effects in vitro and in animal models, including anti-biofilm and immune-signaling roles. LL-37 is not an FDA-approved anti-infective; clinical translation has been limited by issues such as cytotoxicity, salt sensitivity, and potential for bacterial resistance. This entry is a research-reference summary.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent
Review, 2021.
Significance of LL-37 on Immunomodulation and Disease Outcome
Yang B, et al. Biomed Res Int, 2020.
Antimicrobial host defence peptides: Functions and clinical potential (review)
Mookherjee N, et al. Nat Rev Drug Discov, 2020.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.