Mitochondrial & Aging Research//Research Reference
Humanin
Mitochondrial-derived peptide (MTRNR2; 21/24-aa) with cytoprotective activity studied in Alzheimer and aging models.
Technical Dossier
Batch / Lot Number
—
Testing Status
—
Testing Laboratory
—
Test Date
—
Classification
Mitochondrial-derived peptide (MTRNR2; 21/24-aa cytoprotective peptide)
Mechanism / Biological Target
Reported to interact with Bax-family proteins (e.g., BimEL), FPRL1/formyl peptide receptors, and IGFBP3 to suppress apoptosis and stress signaling; protective activity is specific to certain AD-relevant insults rather than a general anti-apoptotic effect.
Research Areas
Mitochondrial BiologyAgingNeuroprotection
Research Overview
Humanin is a small mitochondrial-derived peptide (21 or 24 amino acids depending on translational origin, encoded by the MTRNR2 gene region) discovered as a factor protecting against Alzheimer-disease-relevant apoptotic insults. Preclinical studies report cytoprotective, neuroprotective, and metabolic effects, and levels change with age in some tissues. Evidence is mechanistic/preclinical; no demonstrated clinical efficacy in humans, and humanin is not an approved drug. Mechanistic/preclinical findings should not be conflated with demonstrated clinical effects.
Laboratory Storage & Handling
For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.
References
- The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Review, 2013.
- Humanin and Its Pathophysiological Roles in Aging: A Systematic Review
Biology (systematic review), 2023.
- Neuroprotective Action of Humanin and Humanin Analogues
Karachaliou CE, et al. (review), 2023.
Available Documentation
- Certificate of AnalysisPending / Not yet available
For Research Use Only
Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.