Endocrine Research//Research Reference

HGH (Somatropin)

Recombinant human growth hormone (somatropin) - an approved pharmaceutical protein for growth hormone deficiency; this entry is a research-reference summary, not an approved drug product.

Technical Dossier

Batch / Lot Number

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Testing Status

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Testing Laboratory

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Test Date

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Classification

Recombinant human growth hormone protein (somatropin, rhGH) - 191-amino-acid protein, NOT a small peptide

Mechanism / Biological Target

Binds the growth hormone receptor, activating JAK2/STAT5 signaling to increase IGF-1 and promote linear growth, protein anabolism, and lipolysis.

Research Areas

EndocrinologyGrowthMetabolism

Research Overview

Somatropin is recombinant human growth hormone (rhGH), a 191-amino-acid protein bioequivalent to endogenous pituitary GH. FDA-approved formulations (e.g., Genotropin, Norditropin) are indicated for growth hormone deficiency, Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, and adult GH deficiency. This catalog entry is a research-reference summary only and does not represent or offer an approved pharmaceutical product. GH therapy carries real risks (e.g., fluid retention, glucose intolerance) and requires medical supervision. Research-grade material is distinct from approved somatropin products.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

History of growth hormone therapy
Indian Journal of Endocrinology and Metabolism (review), 2011.
Somatropin for Growth Hormone Deficiency
NCBI Bookshelf / StatPearls, 2024.
Somatotropin in the treatment of growth hormone deficiency and Turner syndrome
Journal of Clinical Research in Pediatric Endocrinology (review), 2012.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.