Reproductive Endocrine Research//Research Reference
HCG (Human Chorionic Gonadotropin)
Glycoprotein hormone; FDA-approved (Pregnyl, Novarel) for ovulation induction and male hypogonadism, distinct from research-grade material.
Technical Dossier
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Testing Status
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Classification
Glycoprotein hormone (heterodimer; alpha-subunit shared with LH/FSH/TSH + beta-hCG)
Mechanism / Biological Target
Binds the LH/choriogonadotropin receptor (LHCGR), a Gs-coupled receptor, to stimulate steroidogenesis: triggering final oocyte maturation and ovulation in women and testosterone production in men.
Research Areas
ReproductionFertilityEndocrinology
Research Overview
Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced in pregnancy that mimics luteinizing hormone (LH). FDA-approved hCG products (e.g., Pregnyl, Novarel; recombinant Ovidrel) are indicated for ovulation induction in women and for hypogonadotropic hypogonadism in men, under medical supervision. This catalog entry is a research-reference summary and does not represent or offer an approved pharmaceutical product. Off-label 'hCG diet' weight-loss use is not supported by adequate evidence and is not represented here. No clinical-use instructions are provided.
Laboratory Storage & Handling
For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.
References
- Human Chorionic Gonadotropin: The Pregnancy Hormone and More
Cole LA. (review), 2012.
- Pharmacokinetics of Human Chorionic Gonadotropin Injection (FDA-approved recombinant hCG context)
2014.
- PREGNYL (chorionic gonadotropin for injection) - FDA label
DailyMed / FDA prescribing information.
Available Documentation
- Certificate of AnalysisPending / Not yet available
For Research Use Only
Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.