Endocrine Research//Research Reference

CJC-1295 No DAC

Modified GHRH(1-29) analog without the DAC (albumin-binding) moiety; distinct from CJC-1295 with DAC.

Technical Dossier

Batch / Lot Number

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Testing Status

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Testing Laboratory

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Test Date

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Classification

Modified GHRH(1-29) analog (tetrasubstituted; without DAC)

Mechanism / Biological Target

Acts at the pituitary GHRH receptor to stimulate pulsatile growth hormone release; the tetrasubstituted sequence resists DPP-IV proteolysis. Lacking DAC, it is not albumin-bound and is cleared rapidly.

Research Areas

EndocrinologyGrowth Hormone Axis

Research Overview

CJC-1295 No DAC (also called modified GRF 1-29) is a tetrasubstituted analog of growth hormone-releasing hormone(1-29) WITHOUT the C-terminal maleimide 'Drug Affinity Complex' (DAC) that enables albumin binding. Without DAC it does NOT covalently bind albumin and has a short plasma half-life (~30 minutes), unlike CJC-1295 with DAC (half-life ~8 days), which is the form studied in published pharmacokinetic and pharmacodynamic trials. Do not conflate the two compounds: the published human GH/IGF-1 data concern the DAC-containing form. Human evidence specific to the 'No DAC' variant is very limited and it is not an approved drug.

Laboratory Storage & Handling

For laboratory/research material only. Store lyophilized material desiccated at -20°C, protected from light and moisture. Avoid repeated freeze-thaw cycles. Handle using appropriate laboratory PPE and follow institutional SOPs. Not for human administration, reconstitution for human use, or diagnostic use.

References

Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates: identification of CJC-1295
Endocrinology, 2005.
Prolonged stimulation of GH and insulin-like growth factor I secretion by CJC-1295 (with DAC) in healthy adults
Journal of Clinical Endocrinology & Metabolism, 2006.
Once-daily administration of CJC-1295 (with DAC), a long-acting GHRH analog, normalizes growth in the GHRH knockout mouse
American Journal of Physiology, 2006.
CJC-1295: a synthetic GHRH analog that covalently binds albumin (pharmacology)
American Journal of Physiology - Endocrinology and Metabolism, 2006.

Available Documentation

Certificate of AnalysisPending / Not yet available

For Research Use Only

Compounds referenced on Peptide Underground are intended for laboratory and research purposes only. They are not intended to diagnose, treat, cure, or prevent any disease and are not intended for human consumption.